Alcohol is one of these drugs that is being metabolized by the liver and drinking too much or drinking for the longer period of times can cause excessive damage to the liver itself and that liver damage occurs because it gets accumulated with a lot of toxins. Combining Cymbalta and alcohol can cause serious side effects to occur. You should not use alcohol if you are taking this medication. If you must drink alcohol, it is recommended that you do so in moderation and only after you have been taking Cymbalta for a period of time. Should you use alcohol and Cymbalta together? The simple answer is probably not, but why is that? One of the first reasons it’s not a good idea to mix alcohol and Cymbalta use is because of the possibility of liver damage. The main reason to avoid mixing alcohol and Cymbalta is the increased risk of liver damage. On its own, Cymbalta can lead to liver damage, so the risk increases significantly if using alcohol and the drug simultaneously. Oct. 17, 2005 -- The FDA and Eli Lilly and Co. have broadened a warning about possible liver problems with Cymbalta, a drug used to treat depression and pain associated with diabetic peripheral neuropathy. Now, that warning will read, Cymbalta should ordinarily not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease, according to a letter to doctors sent by. Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. Your liver’s job is to break down the substances that you consume and to help your body remove the leftover waste and toxins. Alcohol can be a threat to your liver, especially if you drink too much. Avoid drinking alcohol. It may increase your risk of liver damage. It may increase your risk of liver damage. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. Fried, I haven't tried to have drink since starting Cymbalta, simply because I want to make sure all my side effects are gone before I add alcohol into the mix.